Nature Communications (Jan 2017)
Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations
- Yvonne Y Li,
- Grace T. Y. Chung,
- Vivian W. Y. Lui,
- Ka-Fai To,
- Brigette B. Y. Ma,
- Chit Chow,
- John K, S. Woo,
- Kevin Y. Yip,
- Jeongsun Seo,
- Edwin P. Hui,
- Michael K. F. Mak,
- Maria Rusan,
- Nicole G. Chau,
- Yvonne Y. Y. Or,
- Marcus H. N. Law,
- Peggy P. Y. Law,
- Zoey W. Y. Liu,
- Hoi-Lam Ngan,
- Pok-Man Hau,
- Krista R. Verhoeft,
- Peony H. Y. Poon,
- Seong-Keun Yoo,
- Jong-Yeon Shin,
- Sau-Dan Lee,
- Samantha W. M. Lun,
- Lin Jia,
- Anthony W. H. Chan,
- Jason Y. K. Chan,
- Paul B. S. Lai,
- Choi-Yi Fung,
- Suet-Ting Hung,
- Lin Wang,
- Ann Margaret V. Chang,
- Simion I. Chiosea,
- Matthew L. Hedberg,
- Sai-Wah Tsao,
- Andrew C. van Hasselt,
- Anthony T. C. Chan,
- Jennifer R. Grandis,
- Peter S. Hammerman,
- Kwok-Wai Lo
Affiliations
- Yvonne Y Li
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, Cancer Program, Broad Institute of Harvard and MIT
- Grace T. Y. Chung
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Vivian W. Y. Lui
- School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
- Ka-Fai To
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Brigette B. Y. Ma
- Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong
- Chit Chow
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- John K, S. Woo
- Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Kevin Y. Yip
- Department of Computer Science and Engineering, The Chinese University of Hong Kong
- Jeongsun Seo
- Genomic Medicine Institute, Medical Research Center, Seoul National University
- Edwin P. Hui
- Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong
- Michael K. F. Mak
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Maria Rusan
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, Cancer Program, Broad Institute of Harvard and MIT
- Nicole G. Chau
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, Cancer Program, Broad Institute of Harvard and MIT
- Yvonne Y. Y. Or
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Marcus H. N. Law
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Peggy P. Y. Law
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Zoey W. Y. Liu
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Hoi-Lam Ngan
- Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong
- Pok-Man Hau
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Krista R. Verhoeft
- Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong
- Peony H. Y. Poon
- Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong
- Seong-Keun Yoo
- Genomic Medicine Institute, Medical Research Center, Seoul National University
- Jong-Yeon Shin
- Genomic Medicine Institute, Medical Research Center, Seoul National University
- Sau-Dan Lee
- Department of Computer Science and Engineering, The Chinese University of Hong Kong
- Samantha W. M. Lun
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Lin Jia
- School of Biomedical Sciences and Center for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Anthony W. H. Chan
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- Jason Y. K. Chan
- Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Paul B. S. Lai
- Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Choi-Yi Fung
- Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong
- Suet-Ting Hung
- Department of Pharmacology and Pharmacy, School of Biomedical Sciences, Li-Ka Shing Faculty of Medicine, The University of Hong Kong
- Lin Wang
- Department of Pathology, University of Pittsburgh Medical Center
- Ann Margaret V. Chang
- Institute of Pathology, St. Luke’s Medical Center
- Simion I. Chiosea
- Department of Pathology, University of Pittsburgh Medical Center
- Matthew L. Hedberg
- Medical Scientist Training Program, University of Pittsburgh–Carnegie Mellon University
- Sai-Wah Tsao
- School of Biomedical Sciences and Center for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Andrew C. van Hasselt
- Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Anthony T. C. Chan
- Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong
- Jennifer R. Grandis
- Department of Otolaryngology, University of California San Francisco
- Peter S. Hammerman
- Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, Cancer Program, Broad Institute of Harvard and MIT
- Kwok-Wai Lo
- Department of Anatomical & Cellular Pathology, State Key Laboratory in Oncology in South China and Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong
- DOI
- https://doi.org/10.1038/ncomms14121
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Nasopharyngeal cancer is frequently characterized by Epstein-Barr virus infection. Here, using genomic analyses, the authors find that the tumours harbour mutations in genes involved in the NF-κB signalling pathway or overexpress a viral oncoprotein, latent membrane protein 1.
