Nature Communications (Sep 2022)

Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection

  • Juan F. Quintana,
  • Praveena Chandrasegaran,
  • Matthew C. Sinton,
  • Emma M. Briggs,
  • Thomas D. Otto,
  • Rhiannon Heslop,
  • Calum Bentley-Abbot,
  • Colin Loney,
  • Luis de Lecea,
  • Neil A. Mabbott,
  • Annette MacLeod

DOI
https://doi.org/10.1038/s41467-022-33542-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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Detailed insight into how the brain responds to Trypanosoma brucei infection is lacking. Here, single cell and spatial transcriptomics are integrated to characterise this response, identifying a unique crosstalk between microglia and plasma cells.