Comprehensive review on therapeutic and phytochemical exploration of diosmetin: A promising moiety

Abstract

Background: Diosmetin is a biologically active flavonoid present mainly in various citrus plants and is known to exhibit wide range of potential in the treatment of various disorders. Objective: This review aims to include a thorough report on therapeutic potential of diosmetin in various diseases and metabolic disorders. Method: All the information in this article was collated from various research papers from online scientific database such as PubMed, Web of Science and Scopus. Results: It has been evaluated for its anti-inflammatory, antioxidant, antimicrobial, antilipolytic and analgesic activities. A complete literature survey revealed the significant findings about the molecule pertaining to its complete profiling. The present article is a compilation of all the data available so far about the molecule including multitude of sources accounting for the extraction of diosmetin and summation of its curative potency. Diosmetin has been found to be active in treatment and management of multitude of chronic disorders and is known to harbor great potential to be tapped as a dietary supplement and for nutraceutical purposes for the complementary alternative treatment. But it is seen only after the proper clinical trials and toxicity studies that the molecule can be used at clinical and industrial levels because of its wide ranging potential in the treatment of various disorders. Conclusion: The present review article incorporates different sources of diosmetin from which it can be isolated, its phytochemical profile and usage in the management of different pathological conditions as evidenced by preclinical reports.

Keywords

• Diosmetin
• Diosmin
• Flavonoid
• Citrus plants
• Flavonoid glycoside