Journal of Medicinal Plants (Oct 2016)

The effect of hydro-alcoholic extract of Licorice (Glycyrrhiza glabra) rhizome on the isolated Ileum of male rats and its interaction with Nitrergic system

  • M Farokhipour,
  • AA Bahaoddini,
  • E Khoshnam

Journal volume & issue
Vol. 15, no. 60
pp. 39 – 46

Abstract

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Background: The licorice (Glycyrrhiza glabra) rhizome has been widely used in traditional medicine for treatment of gastrointestinal diseases. Objective: In the present study, the effect of hydro-alcoholic extract of licorice rhizome on mechanical activity of isolated ileum of male rats has been studied. Methods: Seven adult male rats were anesthetized by ethyl ether, their abdomen opened, and ileum dissected and divided into 1 cm segments. The segments were connected to a force transducer longitudinally and inserted to an organ bathe contained oxygenated Tyrode solution (37 °C, pH=7.4). Their mechanical activity of ileum was recorded by power lab AD instrument in basal condition, and after administration of L-NAME (10-4M) drug in the presence and absence of licorice rhizome extract (0.0175 mg/ml). Also the mechanical activity of control group segments were recorded at the same condition with extract solvent (ethanol %70). Results: A significant decrease in mechanical activity of the isolated ileum occurred after administration of hydro-alcoholic extract of licorice compared to the control group, while the mechanical activity of ileum tissue not significantly changed in the coadministration of L-NAME and extract between experimental and control groups. Conclusion: We can conclude that hydro-alcoholic extract of licorice has modifying effect on ileum motility, and this activity may be occurred independently to the nitrergic system.

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