Arene C–H borylation strategy enabled by a non-classical boron cluster-based electrophile

Sangmin Kim; Joseph W. Treacy; Yessica A. Nelson; Jordan A. M. Gonzalez; Milan Gembicky; K. N. Houk; Alexander M. Spokoyny

doi:10.1038/s41467-023-37258-6

Nature Communications (Mar 2023)

Arene C–H borylation strategy enabled by a non-classical boron cluster-based electrophile

Sangmin Kim,
Joseph W. Treacy,
Yessica A. Nelson,
Jordan A. M. Gonzalez,
Milan Gembicky,
K. N. Houk,
Alexander M. Spokoyny

Affiliations

Sangmin Kim: Department of Chemistry and Biochemistry, University of California, Los Angeles
Joseph W. Treacy: Department of Chemistry and Biochemistry, University of California, Los Angeles
Yessica A. Nelson: Department of Chemistry and Biochemistry, University of California, Los Angeles
Jordan A. M. Gonzalez: Department of Chemistry and Biochemistry, University of California, Los Angeles
Milan Gembicky: Department of Chemistry and Biochemistry, University of California, San Diego
K. N. Houk: Department of Chemistry and Biochemistry, University of California, Los Angeles
Alexander M. Spokoyny: Department of Chemistry and Biochemistry, University of California, Los Angeles

DOI: https://doi.org/10.1038/s41467-023-37258-6
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 9

Abstract

Read online

Electrophilic borylation of sterically hindered arenes is a challenging transformation. Here, authors report a metal-free electrophilic C–H borylation of hindered arenes using a boron cluster reagent producing valuable aryl boronic esters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal