Stem Cell Research (Aug 2017)

Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient

  • Yuchang Chen,
  • Zhanhui Ou,
  • Bing Song,
  • Yexing Xian,
  • Shuming Ouyang,
  • Yuhuan Xie,
  • Yanting Xue,
  • Xiaofang Sun

DOI
https://doi.org/10.1016/j.scr.2017.06.002
Journal volume & issue
Vol. 23, no. C
pp. 57 – 60

Abstract

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47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human induced pluripotent stem cell line (GZHMUi001-A) by using Sendai virus to reprogram peripheral blood mononuclear cells from a 47, XXX syndrome patient with premature ovarian failure. This 47, XXX iPS cell line has characteristics of pluripotent stem cells and is a useful tool for the investigation of this X chromosome aneuploid disease.