BMJ Open (Jun 2022)
Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort
- ,
- Thorarinn Gislason,
- Torben Sigsgaard,
- Vivi Schlünssen,
- Joachim Heinrich,
- Jesús Martínez-Moratalla,
- Øistein Svanes,
- Mathias Holm,
- Bertil Forsberg,
- Dan Norbäck,
- Rain Jogi,
- Kjell Torén,
- Deborah Jarvis,
- Magnus Ekström,
- Adrian Lowe,
- Caroline J Lodge,
- Michael Abramson,
- Shyamali Dharmage,
- Kathrine Pape,
- Cecilie Svanes,
- Gita Mishra,
- Caroline Lodge,
- Lyle Gurrin,
- Bruce Thompson,
- Eva Lindberg,
- Christer Janson,
- Simone Accordini,
- Ane Johannessen,
- Bryndis Benediktsdottir,
- Karl Franklin,
- Andrei Malinovschi,
- Anna Oudin,
- Francisco Gómez Real,
- José Luis Sánchez-Ramos,
- Lennart Bråbäck,
- Torgeir Storaas,
- Shanshan Xu,
- Julia Dratva,
- John Holloway,
- Jorunn Kirkeleit,
- Christine Cramer,
- Gro Tjalvin,
- Anne Mette Lund Würtz,
- Randi Jacobsen Bertelsen,
- Oskar Jõgi,
- Signe Timm,
- Francisco Javier Callejas,
- Raúl Godoy,
- Trude Duelien Skorge,
- Christine Drengenes,
- Nils Oskar Jõgi,
- Maryia Khomich,
- Toril Mørkve Knudsen,
- Ingrid Kuiper,
- Juan Pablo López-Cervantes,
- Marianne Lønnebotn,
- Shokouh Makvandi-Nejad,
- Antonio Pérez,
- Anders Røsland,
- Rajesh Shigdel,
- Svein Magne Skulstad,
- Kai Triebner,
- Hilde Vindenes,
- Jose Luis Sanchez,
- Jose Maldonado,
- David Martino,
- Jennifer Perret,
- Lucia Calciano,
- William Horsnell,
- Susanne Krauss-Etchmann
Affiliations
- Thorarinn Gislason
- Landspitali University Hospital, Reykjavik, Iceland
- Torben Sigsgaard
- Department of Public Health, Research Unit for Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
- Vivi Schlünssen
- Department of Public Health, Research Unit for Environment Occupation and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark
- Joachim Heinrich
- 14 Department of psychology, Institute and Clinic for Occupational, Social and Environmental Medicine, Ludwig Maximilians University Munich, Munchen, Germany
- Jesús Martínez-Moratalla
- Servicio de Neumología, Complejo Hospitalario Universitario de Albacete, Albacete, Spain
- Øistein Svanes
- 23 Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway
- Mathias Holm
- Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
- Bertil Forsberg
- professor
- Dan Norbäck
- 27 Department of Medical Sciences, Uppsala University, Uppsala, Sweden
- Rain Jogi
- Lung Clinic, Tartu University Hospital, Tartu, Estonia
- Kjell Torén
- Occupational and Environmental Medicine, School of Public Health and Community Medicine, University of Gothenburg Institute of Medicine, Goteborg, Sweden
- Deborah Jarvis
- Magnus Ekström
- Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund, Sweden
- Adrian Lowe
- Caroline J Lodge
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia
- Michael Abramson
- Monash University, Melbourne, Australia
- Shyamali Dharmage
- Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
- Kathrine Pape
- Cecilie Svanes
- Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen Faculty of Medicine and Dentistry, Bergen, Norway
- Gita Mishra
- School of Public Health, The University of Queensland, Saint Lucia, Queensland, Australia
- Caroline Lodge
- Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
- Lyle Gurrin
- Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
- Bruce Thompson
- Health Sciences, Swinburne University of Technology, Melbourne, Victoria, Australia
- Eva Lindberg
- 1 Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University Faculty of Medicine, Uppsala, Sweden
- Christer Janson
- Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
- Simone Accordini
- Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy
- Ane Johannessen
- 2Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
- Bryndis Benediktsdottir
- Faculty of Medicine, University of Iceland, Reykjavik, Iceland
- Karl Franklin
- 5 Department of Surgical and Perioperative Sciences, Surgery, Umeå University, Umea, Sweden
- Andrei Malinovschi
- Medical Sciences, Uppsala University, Uppsala, Sweden
- Anna Oudin
- Department of Public Health and Clinical Medicine, Umeå University, Umea, Sweden
- Francisco Gómez Real
- Department of Clinical Science, University of Bergen, Bergen, Norway
- José Luis Sánchez-Ramos
- Department of Nursing, University of Huelva, Huelva, Spain
- Lennart Bråbäck
- Section of Sustainable Health, Department of Public Health and Clinical Medicine, Umeå Universitet, Umeå, Sweden
- Torgeir Storaas
- Shanshan Xu
- Department of Pharmacy, Beijing Tongren Hospital, Beijing, China
- Julia Dratva
- John Holloway
- Jorunn Kirkeleit
- Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Oslo, Norway
- Christine Cramer
- 5Department of Public Health, Research Unit for Work, Environment and Health, Danish Ramazzini Centre, Aarhus University, DK-8000 Aarhus C, Denmark
- Gro Tjalvin
- Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway
- Anne Mette Lund Würtz
- 1Netherlands Organization for Applied Scientific Research (TNO), The Netherlands
- Randi Jacobsen Bertelsen
- Department of Clinical Science, University of Bergen, Bergen, Norway
- Oskar Jõgi
- Department of Clinical Science, University of Bergen, Bergen, Norway
- Signe Timm
- Department of Oncology, Lillebaelt Hospital-University Hospital of Southern Denmark, Vejle, Denmark
- Francisco Javier Callejas
- Department of Respiratory Medicine, Albacete University Hospital Complex, Albacete, Spain
- Raúl Godoy
- Trude Duelien Skorge
- Christine Drengenes
- 2 Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway
- Nils Oskar Jõgi
- Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
- Maryia Khomich
- Toril Mørkve Knudsen
- Ingrid Kuiper
- Juan Pablo López-Cervantes
- Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen Faculty of Medicine and Dentistry, Bergen, Norway
- Marianne Lønnebotn
- Shokouh Makvandi-Nejad
- Antonio Pérez
- Anders Røsland
- Rajesh Shigdel
- Svein Magne Skulstad
- Kai Triebner
- Hilde Vindenes
- Jose Luis Sanchez
- Hospital Universitari Vall Hebrón, Barcelona, Spain
- Jose Maldonado
- David Martino
- Jennifer Perret
- Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia
- Lucia Calciano
- Epidemiological Department, Azienda Zero, Padova, Italy
- William Horsnell
- Department of Pathology, University of Cape Town, Cape Town, South Africa
- Susanne Krauss-Etchmann
- DOI
- https://doi.org/10.1136/bmjopen-2021-059434
- Journal volume & issue
-
Vol. 12,
no. 6
Abstract
Purpose The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how exposures before conception and in previous generations influence health and disease, particularly allergies and respiratory health, (2) identify susceptible time windows and (3) explore underlying mechanisms. The ultimate aim is to facilitate efficient intervention strategies targeting multiple generations.Participants RHINESSA includes study participants of multiple generations from ten study centres in Norway (1), Denmark (1), Sweden (3), Iceland (1), Estonia (1), Spain (2) and Australia (1). The RHINESSA core cohort, adult offspring generation 3 (G3), was first investigated in 2014–17 in a questionnaire study (N=8818, age 18–53 years) and a clinical study (subsample, n=1405). Their G2 parents participated in the population-based cohorts, European Community Respiratory Heath Survey and Respiratory Health In Northern Europe, followed since the early 1990s when they were 20–44 years old, at 8–10 years intervals. Study protocols are harmonised across generations.Findings to date Collected data include spirometry, skin prick tests, exhaled nitric oxide, anthropometrics, bioimpedance, blood pressure; questionnaire/interview data on respiratory/general/reproductive health, indoor/outdoor environment, smoking, occupation, general characteristics and lifestyle; biobanked blood, urine, gingival fluid, skin swabs; measured specific and total IgE, DNA methylation, sex hormones and oral microbiome. Research results suggest that parental environment years before conception, in particular, father’s exposures such as smoking and overweight, may be of key importance for asthma and lung function, and that there is an important susceptibility window in male prepuberty. Statistical analyses developed to approach causal inference suggest that these associations may be causal. DNA methylation studies suggest a mechanism for transfer of father’s exposures to offspring health and disease through impact on offspring DNA methylation.Future plans Follow-up is planned at 5–8 years intervals, first in 2021–2023. Linkage with health registries contributes to follow-up of the cohort.
