Морфологія (Jan 2007)
Estrogen and progesterone expression in displastic and neoplastic cervical lesions.
Abstract
Cancer and precancerous lesions of cervix uteri are one of the primary medical, psychological and social problems of women worldwide. That is why the analysis of immunohistochemical marker expression is gaining in importance in clinical oncology nowadays in order to substantiate rational treatment regimen and to detect risk groups. Therefore the purpose of this study was to estimate estrogen and progesterone receptor expression in displastic and neoplastic cervical lesions and their relation to persistent oncogenic human papillomavirus infection. Operating and bioptic material from 89 patients after hysterectomy, conization of cervix and colposcopy with biopsy of cervical tissue under visual control was investigated and diagnoses such as CINI, CINII, CINIII, invasive carcinoma were confirmed. Inverse relationships among the degree of cervical lesion, intensity of staining for estrogen receptors, as well as presence of DNA of oncogenic human papillomavirus was determined. Positive staining for progesterone receptors in cervical adenocarcinomas inversely correlates with histological grade of tumors. Apparently, estrogen and progesterone play an important role in oncotransformation process in persistent oncogenic human papillomavirus infection. We can also speculate that estrogen and progesterone are cofactors of progression of displastic cervical lesion in neoplastic ones.
