Nature Communications (Mar 2023)
MYTHO is a novel regulator of skeletal muscle autophagy and integrity
- Jean-Philippe Leduc-Gaudet,
- Anais Franco-Romero,
- Marina Cefis,
- Alaa Moamer,
- Felipe E. Broering,
- Giulia Milan,
- Roberta Sartori,
- Tomer Jordi Chaffer,
- Maude Dulac,
- Vincent Marcangeli,
- Dominique Mayaki,
- Laurent Huck,
- Anwar Shams,
- José A. Morais,
- Elise Duchesne,
- Hanns Lochmuller,
- Marco Sandri,
- Sabah N. A. Hussain,
- Gilles Gouspillou
Affiliations
- Jean-Philippe Leduc-Gaudet
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
- Anais Franco-Romero
- Veneto Institute of Molecular Medicine
- Marina Cefis
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal
- Alaa Moamer
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
- Felipe E. Broering
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
- Giulia Milan
- Veneto Institute of Molecular Medicine
- Roberta Sartori
- Veneto Institute of Molecular Medicine
- Tomer Jordi Chaffer
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
- Maude Dulac
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal
- Vincent Marcangeli
- Département des Sciences de l’Activité Physique, Faculté des Sciences, Université du Québec à Montréal
- Dominique Mayaki
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
- Laurent Huck
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
- Anwar Shams
- Department of Pharmacology, College of Medicine, Taif University
- José A. Morais
- Division of Geriatric Medicine, MUHC-Montreal General Hospital, McGill University
- Elise Duchesne
- Département des Sciences de la Santé, Unité d’Enseignement en Physiothérapie, Université du Québec à Chicoutimi
- Hanns Lochmuller
- Children’s Hospital of Eastern Ontario Research Institute
- Marco Sandri
- Department of Critical Care, McGill University Health Centre
- Sabah N. A. Hussain
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
- Gilles Gouspillou
- Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
- DOI
- https://doi.org/10.1038/s41467-023-36817-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
Here, the authors identify a novel regulator of autophagy, skeletal muscle mass and integrity named MYTHO. Silencing MYTHO protects against muscle atrophy in a wide range of acute catabolic conditions, while prolonged silencing causes a severe myopathy.
