Markers of endothelial dysfunction in pregnant women with the A2 gene polymorphism of platelet glycoprotein receptors IIb/IIIa

Abstract

The role of gene polymorphism A2 receptors platelet glycoprotein IIb/IIIa in the development of systemic endothelial dysfunction in pregnant women. Patients A2 polymorphism observed increase in markers of endothelial dysfunction, increased production of pro-inflammatory cytokines, increased free-radical reactions, decreased antioxidant activity, especially in the group of women with the polymorphism P1A2/P1A2.

Keywords

• тромбофилия
• дисфункция эндотелия
• полиморфизм генов
• thrombophilia
• endothelial dysfunction
• gene polymorphism