Nature Communications (Sep 2016)
ICER is requisite for Th17 differentiation
- Nobuya Yoshida,
- Denis Comte,
- Masayuki Mizui,
- Kotaro Otomo,
- Florencia Rosetti,
- Tanya N. Mayadas,
- José C. Crispín,
- Sean J. Bradley,
- Tomohiro Koga,
- Michihito Kono,
- Maria P. Karampetsou,
- Vasileios C. Kyttaris,
- Klaus Tenbrock,
- George C. Tsokos
Affiliations
- Nobuya Yoshida
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Denis Comte
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Masayuki Mizui
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Kotaro Otomo
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Florencia Rosetti
- Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women’s Hospital, Harvard Medical School
- Tanya N. Mayadas
- Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women’s Hospital, Harvard Medical School
- José C. Crispín
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Sean J. Bradley
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Tomohiro Koga
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Michihito Kono
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Maria P. Karampetsou
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Vasileios C. Kyttaris
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- Klaus Tenbrock
- Department of Pediatrics, Division of Allergology and Immunology, RWTH University of Aachen
- George C. Tsokos
- Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School
- DOI
- https://doi.org/10.1038/ncomms12993
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
ICER is a CREM splice variant that represses CREM/CREB signalling. Here the authors use human cells and mouse models of various autoimmune diseases to show that ICER is central to pathogenic Th17 cell differentiation in autoimmunity.
