Synergistic approach to polycycles through Suzuki–Miyaura cross coupling and metathesis as key steps

Abstract

This account provides an overview of recent work, including our own contribution dealing with Suzuki–Miyaura cross coupling in combination with metathesis (or vice-versa). Several cyclophanes, polycycles, macrocycles, spirocycles, stilbenes, biaryls, and heterocycles have been synthesized by employing a combination of Suzuki cross-coupling and metathesis. Various popular reactions such as Diels–Alder reaction, Claisen rearrangement, cross-metathesis, and cross-enyne metathesis are used. The synergistic combination of these powerful reactions is found to be useful for the construction of complex targets and fulfill synthetic brevity.

Keywords

• Claisen rearrangement
• Diels–Alder reaction
• metathesis
• polycycles
• Suzuki–Miyaura cross coupling