Nature Communications (Mar 2023)
Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells
- Maria A. Missinato,
- Sean Murphy,
- Michaela Lynott,
- Michael S. Yu,
- Anaïs Kervadec,
- Yu-Ling Chang,
- Suraj Kannan,
- Mafalda Loreti,
- Christopher Lee,
- Prashila Amatya,
- Hiroshi Tanaka,
- Chun-Teng Huang,
- Pier Lorenzo Puri,
- Chulan Kwon,
- Peter D. Adams,
- Li Qian,
- Alessandra Sacco,
- Peter Andersen,
- Alexandre R. Colas
Affiliations
- Maria A. Missinato
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Sean Murphy
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Michaela Lynott
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Michael S. Yu
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Anaïs Kervadec
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Yu-Ling Chang
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Suraj Kannan
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Mafalda Loreti
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Christopher Lee
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Prashila Amatya
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Hiroshi Tanaka
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Chun-Teng Huang
- Viral Vector Core Facility Sanford Burnham Prebys Medical Discovery Institute
- Pier Lorenzo Puri
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Chulan Kwon
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Peter D. Adams
- Tumor Initiation and Maintenance Program, Sanford Burnham Prebys Medical Discovery Institute
- Li Qian
- McAllister Heart Institute, University of North Carolina at Chapel Hill
- Alessandra Sacco
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- Peter Andersen
- Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine
- Alexandre R. Colas
- Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute
- DOI
- https://doi.org/10.1038/s41467-023-37256-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Transdifferentiation has been proposed as an approach for regenerative medicine, but the mechanisms that safeguard cell identity are not well established. Here they identify transcription factors that oppose transdifferentiation and show that knockdown of these genes improves recovery after myocardial infarction.
