Nature Communications (Jul 2017)
TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus
- Joaquin I. Hurtado-Zavala,
- Binu Ramachandran,
- Saheeb Ahmed,
- Rashi Halder,
- Christiane Bolleyer,
- Ankit Awasthi,
- Markus A. Stahlberg,
- Robin J. Wagener,
- Kristin Anderson,
- Ryan M. Drenan,
- Henry A. Lester,
- Julie M. Miwa,
- Jochen F. Staiger,
- Andre Fischer,
- Camin Dean
Affiliations
- Joaquin I. Hurtado-Zavala
- Trans-synaptic Signaling Group, European Neuroscience Institute
- Binu Ramachandran
- Trans-synaptic Signaling Group, European Neuroscience Institute
- Saheeb Ahmed
- Trans-synaptic Signaling Group, European Neuroscience Institute
- Rashi Halder
- Department of Epigenetics and Systems Medicine in Neurodegenerative Disease, German Center for Neurodegenerative Disease, University Medical Center Goettingen
- Christiane Bolleyer
- Trans-synaptic Signaling Group, European Neuroscience Institute
- Ankit Awasthi
- Trans-synaptic Signaling Group, European Neuroscience Institute
- Markus A. Stahlberg
- Trans-synaptic Signaling Group, European Neuroscience Institute
- Robin J. Wagener
- Institute for Neuroanatomy, University Medical Center Goettingen
- Kristin Anderson
- Biological Sciences Department, Lehigh University
- Ryan M. Drenan
- Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University
- Henry A. Lester
- Division of Biology and Biological Engineering, California Institute of Technology
- Julie M. Miwa
- Biological Sciences Department, Lehigh University
- Jochen F. Staiger
- Institute for Neuroanatomy, University Medical Center Goettingen
- Andre Fischer
- Department of Epigenetics and Systems Medicine in Neurodegenerative Disease, German Center for Neurodegenerative Disease, University Medical Center Goettingen
- Camin Dean
- Trans-synaptic Signaling Group, European Neuroscience Institute
- DOI
- https://doi.org/10.1038/ncomms15878
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 20
Abstract
The role of TRPV1 in the CNS is not fully understood. Here the authors show that TRPV1 is expressed specifically in somatostatin-positive OLM interneurons of the hippocampus, where it promotes excitatory innervation of these cells.
