Вопросы вирусологии (Jan 2021)

Peculiarities of the influenza and ARVI viruses circulation during epidemic season 2019–2020 in some regions of Russia

  • D. K. L’vov,
  • E. I. Burtseva,
  • L. V. Kolobukhina,
  • I. T. Fedyakina,
  • N. V. Bovin,
  • A. V. Ignatjeva,
  • K. G. Krasnoslobodtsev,
  • E. L. Feodoritova,
  • S. V. Trushakova,
  • N. V. Breslav,
  • L. N. Merkulova,
  • E. A. Mukasheva,
  • I. N. Khlopova,
  • O. L. Voronina,
  • E. I. Aksyonova,
  • M. S. Kunda,
  • N. N. Ryzhova,
  • R. V. Vartanjan,
  • L. B. Kistenyova,
  • I. M. Kirillov,
  • E. S. Proshina,
  • A. G. Rosatkevich,
  • I. S. Kruzhkova,
  • A. L. Zaplatnikov,
  • M. V. Bazarova,
  • S. V. Smetanina,
  • M. V. Kharlamov,
  • N. L. Karpov,
  • A. V. Shikhin

DOI
https://doi.org/10.36233/0507-4088-2020-65-6-4
Journal volume & issue
Vol. 65, no. 6
pp. 335 – 349

Abstract

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Introduction. The surveillance of influenza viruses in ARVI structure and study of their properties in epidemic season 2019–2020 in Russian Federation are actual for investigations due to tasks of Global Influenza Strategy initiated by WHO in 2019. Material and methods. The data of epidemiological surveillance on influenza- and ARVI-associated morbidity and hospitalization in different age groups of population were analyzed; virological, genetic and statistical methods were used. Results. Preschool children were involved in epidemic the most. Meanwhile, the highest rate of hospitalization was observed in patients of 18–40 years old. Influenza A(H1N1)pdm09 virus dominated in etiology of ARVI in hospitalized patients and pneumonia. The role of respiratory viruses in severe cases of pneumonia and bronchoalveolar syndrome in children was shown. The differences in spectrum of circulating viruses caused ARVI in different regions of Russia were found. Influenza A(H1N1)pdm09 and B/Victoria-like viruses were the main etiological agents that caused of epidemic; its activity among all ARVI was 7.3 and 8.0%, respectively. The differences in antigenic properties of influenza A(H3N2) and B epidemic strains compared to vaccine viruses were found. The populations of epidemic strains were presented by following dominant genetic groups: 6B1.A5/183P for A(H1N1)pdm09, 3С.2а1b+137F for A(H3N2) and V1A.3 line B/Victoria-like for B viruses. The good profile of epidemic strains susceptibility to anti-neuraminidase inhibitors has been saved. The most of the studied influenza strains had the receptor specificity characteristic of human influenza viruses. Conclusions. Obtained results identified the peculiarities of viruses caused the influenza and ARVI in epidemic season 2019–2020 in different regions of Russia. These results suggested the important role of influenza A(H1N1) pdm09 in severe cases and pneumonia in adults 18–40 years old. The continuing drift in influenza viruses was found, which, apparently, could not but affect the efficacy of vaccine prophylaxis and was also considered in the recommendations of WHO experts on the composition of influenza vaccines for the countries of the Northern Hemisphere in the 2020–2021 season.

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