An Improved Synthesis of 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (a VX-745 analog)

Abstract

An improved procedure for the synthesis an analog of the p38 inhibitor compound VX- 745 is reported.

Keywords

• nucleophilic substitution
• DMF-acetal heterocyclization