Nature Communications (Nov 2019)

MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance

  • Israel Salguero,
  • Rimma Belotserkovskaya,
  • Julia Coates,
  • Matylda Sczaniecka-Clift,
  • Mukerrem Demir,
  • Satpal Jhujh,
  • Marcus D. Wilson,
  • Stephen P. Jackson

DOI
https://doi.org/10.1038/s41467-019-12929-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

MDC1 and H2AX interact and accumulate at sites of DNA damage, functioning to recruit additional factors involved in the repair process. Here the authors uncover a function for MDC1 that is independent of the presence of H2AX and is mediated through its PST-repeat region.