Nature Communications (May 2021)
Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons
- Sun-Gyun Kim,
- Suho Lee,
- Yangsik Kim,
- Jieun Park,
- Doyeon Woo,
- Dayeon Kim,
- Yan Li,
- Wangyong Shin,
- Hyunjeong Kang,
- Chaehyun Yook,
- Minji Lee,
- Kyungdeok Kim,
- Junyeop Daniel Roh,
- Jeseung Ryu,
- Hwajin Jung,
- Seung Min Um,
- Esther Yang,
- Hyun Kim,
- Jinju Han,
- Won Do Heo,
- Eunjoon Kim
Affiliations
- Sun-Gyun Kim
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Suho Lee
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Yangsik Kim
- Graduate School of Medical Science and Engineering, Korea Advanced Institute for Science and Technology (KAIST)
- Jieun Park
- Department of Biological Sciences, KAIST
- Doyeon Woo
- Center for Cognition and Sociality, Institute for Basic Science (IBS)
- Dayeon Kim
- Graduate School of Medical Science and Engineering, Korea Advanced Institute for Science and Technology (KAIST)
- Yan Li
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Wangyong Shin
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Hyunjeong Kang
- Department of Biological Sciences, KAIST
- Chaehyun Yook
- Department of Biological Sciences, KAIST
- Minji Lee
- Center for Cognition and Sociality, Institute for Basic Science (IBS)
- Kyungdeok Kim
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Junyeop Daniel Roh
- Department of Biological Sciences, KAIST
- Jeseung Ryu
- Department of Biological Sciences, KAIST
- Hwajin Jung
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- Seung Min Um
- Department of Biological Sciences, KAIST
- Esther Yang
- Department of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea University
- Hyun Kim
- Department of Anatomy and Division of Brain Korea 21, Biomedical Science, College of Medicine, Korea University
- Jinju Han
- Graduate School of Medical Science and Engineering, Korea Advanced Institute for Science and Technology (KAIST)
- Won Do Heo
- Department of Biological Sciences, KAIST
- Eunjoon Kim
- Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
- DOI
- https://doi.org/10.1038/s41467-021-22908-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Alterations of the mTOR signalling pathway are associated with neurodevelopmental defects. Regulators of the mTOR kinase activity are not fully described. Here, the authors show that Tanc2, a scaffolding protein, acts as a direct inhibitor of mTOR kinase activity in the developing mouse brain and cultured human neurons.
