Nature Communications (Apr 2021)
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
- Benjamin Caballero,
- Mathieu Bourdenx,
- Enrique Luengo,
- Antonio Diaz,
- Peter Dongmin Sohn,
- Xu Chen,
- Chao Wang,
- Yves R. Juste,
- Susanne Wegmann,
- Bindi Patel,
- Zapporah T. Young,
- Szu Yu Kuo,
- Jose Antonio Rodriguez-Navarro,
- Hao Shao,
- Manuela G. Lopez,
- Celeste M. Karch,
- Alison M. Goate,
- Jason E. Gestwicki,
- Bradley T. Hyman,
- Li Gan,
- Ana Maria Cuervo
Affiliations
- Benjamin Caballero
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Mathieu Bourdenx
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Enrique Luengo
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Antonio Diaz
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Peter Dongmin Sohn
- Helen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell Medicine
- Xu Chen
- Helen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell Medicine
- Chao Wang
- Helen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell Medicine
- Yves R. Juste
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Susanne Wegmann
- Massachusetts General Hospital, Harvard Medical School
- Bindi Patel
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Zapporah T. Young
- Institute for Neurodegenerative Disease, University of California at San Francisco
- Szu Yu Kuo
- Institute for Neurodegenerative Disease, University of California at San Francisco
- Jose Antonio Rodriguez-Navarro
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- Hao Shao
- Institute for Neurodegenerative Disease, University of California at San Francisco
- Manuela G. Lopez
- Institute Teofilo Hernando for Drug Discovery, Department of Pharmacology, School of Medicine, Universidad Autonoma de Madrid
- Celeste M. Karch
- Department of Psychiatry, Washington University
- Alison M. Goate
- Department of Neuroscience, Icahn School of Medicine at Mount Sinai
- Jason E. Gestwicki
- Institute for Neurodegenerative Disease, University of California at San Francisco
- Bradley T. Hyman
- Massachusetts General Hospital, Harvard Medical School
- Li Gan
- Helen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell Medicine
- Ana Maria Cuervo
- Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-22501-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathways and increasing extracellular tau release.
