Nature Communications (Apr 2021)

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

  • Benjamin Caballero,
  • Mathieu Bourdenx,
  • Enrique Luengo,
  • Antonio Diaz,
  • Peter Dongmin Sohn,
  • Xu Chen,
  • Chao Wang,
  • Yves R. Juste,
  • Susanne Wegmann,
  • Bindi Patel,
  • Zapporah T. Young,
  • Szu Yu Kuo,
  • Jose Antonio Rodriguez-Navarro,
  • Hao Shao,
  • Manuela G. Lopez,
  • Celeste M. Karch,
  • Alison M. Goate,
  • Jason E. Gestwicki,
  • Bradley T. Hyman,
  • Li Gan,
  • Ana Maria Cuervo

Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18


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The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathways and increasing extracellular tau release.