Nature Communications (Jun 2021)
Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers
- Edurne Rujas,
- Iga Kucharska,
- Yong Zi Tan,
- Samir Benlekbir,
- Hong Cui,
- Tiantian Zhao,
- Gregory A. Wasney,
- Patrick Budylowski,
- Furkan Guvenc,
- Jocelyn C. Newton,
- Taylor Sicard,
- Anthony Semesi,
- Krithika Muthuraman,
- Amy Nouanesengsy,
- Clare Burn Aschner,
- Katherine Prieto,
- Stephanie A. Bueler,
- Sawsan Youssef,
- Sindy Liao-Chan,
- Jacob Glanville,
- Natasha Christie-Holmes,
- Samira Mubareka,
- Scott D. Gray-Owen,
- John L. Rubinstein,
- Bebhinn Treanor,
- Jean-Philippe Julien
Affiliations
- Edurne Rujas
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Iga Kucharska
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Yong Zi Tan
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Samir Benlekbir
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Hong Cui
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Tiantian Zhao
- Department of Immunology, University of Toronto
- Gregory A. Wasney
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Patrick Budylowski
- Combined Containment Level 3 Unit, University of Toronto
- Furkan Guvenc
- Combined Containment Level 3 Unit, University of Toronto
- Jocelyn C. Newton
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Taylor Sicard
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Anthony Semesi
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Krithika Muthuraman
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Amy Nouanesengsy
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Clare Burn Aschner
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Katherine Prieto
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Stephanie A. Bueler
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Sawsan Youssef
- Distributed Bio
- Sindy Liao-Chan
- Distributed Bio
- Jacob Glanville
- Distributed Bio
- Natasha Christie-Holmes
- Combined Containment Level 3 Unit, University of Toronto
- Samira Mubareka
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Scott D. Gray-Owen
- Department of Molecular Genetics, University of Toronto
- John L. Rubinstein
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- Bebhinn Treanor
- Department of Immunology, University of Toronto
- Jean-Philippe Julien
- Program in Molecular Medicine, The Hospital for Sick Children Research Institute
- DOI
- https://doi.org/10.1038/s41467-021-23825-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Here, the authors combine three different antibody specificities and an Fc domain on a single multivalent molecule, resulting in high neutralization activity despite viral sequence variability.
