Nature Communications (Jul 2017)
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice
- Kan Xie,
- Frauke Neff,
- Astrid Markert,
- Jan Rozman,
- Juan Antonio Aguilar-Pimentel,
- Oana Veronica Amarie,
- Lore Becker,
- Robert Brommage,
- Lillian Garrett,
- Kristin S. Henzel,
- Sabine M. Hölter,
- Dirk Janik,
- Isabelle Lehmann,
- Kristin Moreth,
- Brandon L. Pearson,
- Ildiko Racz,
- Birgit Rathkolb,
- Devon P. Ryan,
- Susanne Schröder,
- Irina Treise,
- Raffi Bekeredjian,
- Dirk H. Busch,
- Jochen Graw,
- Gerhard Ehninger,
- Martin Klingenspor,
- Thomas Klopstock,
- Markus Ollert,
- Michael Sandholzer,
- Carsten Schmidt-Weber,
- Marco Weiergräber,
- Eckhard Wolf,
- Wolfgang Wurst,
- Andreas Zimmer,
- Valerie Gailus-Durner,
- Helmut Fuchs,
- Martin Hrabě de Angelis,
- Dan Ehninger
Affiliations
- Kan Xie
- DZNE, German Center for Neurodegenerative Diseases
- Frauke Neff
- Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Astrid Markert
- DZNE, German Center for Neurodegenerative Diseases
- Jan Rozman
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Juan Antonio Aguilar-Pimentel
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Oana Veronica Amarie
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Lore Becker
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Robert Brommage
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Lillian Garrett
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Kristin S. Henzel
- DZNE, German Center for Neurodegenerative Diseases
- Sabine M. Hölter
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Dirk Janik
- Institute of Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Isabelle Lehmann
- DZNE, German Center for Neurodegenerative Diseases
- Kristin Moreth
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Brandon L. Pearson
- DZNE, German Center for Neurodegenerative Diseases
- Ildiko Racz
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Birgit Rathkolb
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Devon P. Ryan
- DZNE, German Center for Neurodegenerative Diseases
- Susanne Schröder
- DZNE, German Center for Neurodegenerative Diseases
- Irina Treise
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Raffi Bekeredjian
- Department of Medicine III, Division of Cardiology, University of Heidelberg
- Dirk H. Busch
- Institute for Medical Microbiology, Immunology, and Hygiene, Trogerstraße 30, Technische Universität München
- Jochen Graw
- Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Gerhard Ehninger
- Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden
- Martin Klingenspor
- Molecular Nutritional Medicine, Else Kröner-Fresenius Center, Technische Universität München
- Thomas Klopstock
- Friedrich-Baur-Institut, Department of Neurology, Ludwig-Maximilians-Universität München
- Markus Ollert
- Department of Infection and Immunity, Luxembourg Institute of Health
- Michael Sandholzer
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Carsten Schmidt-Weber
- Center of Allergy & Environment (ZAUM), Technische Universität München and Helmholtz Zentrum München
- Marco Weiergräber
- Research Group Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices
- Eckhard Wolf
- Chair of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-Universität München
- Wolfgang Wurst
- Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Andreas Zimmer
- Institute of Molecular Psychiatry, Medical Faculty, University of Bonn
- Valerie Gailus-Durner
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Helmut Fuchs
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Martin Hrabě de Angelis
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health
- Dan Ehninger
- DZNE, German Center for Neurodegenerative Diseases
- DOI
- https://doi.org/10.1038/s41467-017-00178-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
Dietary restriction can extend the life of various model organisms. Here, Xie et al. show that intermittent periods of fasting achieved through every-other-day feeding protect mice against neoplastic disease but do not broadly delay organismal aging in animals.
