Nature Communications (Dec 2021)

CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes

  • Charlotte Douglas,
  • Valdone Maciulyte,
  • Jasmin Zohren,
  • Daniel M. Snell,
  • Shantha K. Mahadevaiah,
  • Obah A. Ojarikre,
  • Peter J. I. Ellis,
  • James M. A. Turner

DOI
https://doi.org/10.1038/s41467-021-27227-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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In areas such as animal research and agriculture a single sex is often required in abundance, leading to wasted resources and ethical considerations. Here the authors develop a CRISPR/Cas9 mediated synthetic lethal system that enables the production of single sex offspring that can be repurposed for use in multiple organisms.