Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast

Soyun Lee; Seunghee Oh; Kwiwan Jeong; Hyelim Jo; Yoonjung Choi; Hogyu David Seo; Minhoo Kim; Joonho Choe; Chang Seob Kwon; Daeyoup Lee

doi:10.1038/s41467-017-02759-8

Nature Communications (Jan 2018)

Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast

Soyun Lee,
Seunghee Oh,
Kwiwan Jeong,
Hyelim Jo,
Yoonjung Choi,
Hogyu David Seo,
Minhoo Kim,
Joonho Choe,
Chang Seob Kwon,
Daeyoup Lee

Affiliations

Soyun Lee: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Seunghee Oh: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Kwiwan Jeong: Biocenter, Gyeonggi Business & Science Accelerator
Hyelim Jo: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Yoonjung Choi: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Hogyu David Seo: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Minhoo Kim: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Joonho Choe: Department of Biological Sciences, Korea Advanced Institute of Science and Technology
Chang Seob Kwon: Department of Chemistry and Biology, Korea Science Academy of KAIST
Daeyoup Lee: Department of Biological Sciences, Korea Advanced Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-017-02759-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Dot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed regions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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