Nanofibrous biologically soluble scaffolds as an effective drug delivery system

Abstract

In this article, the synthesis of biocompatible fibrous scaffolds with antimicrobial properties based on polycaprolactone/hydroxyapatite/amoxicillin and study of their surface morphology, antimicrobial effect, and drug release are discussed. Hydroxyapatite (1–2 $\mu $m, 97%) synthesized from biologically waste material (eggshell) was added to the composite scaffolds as a bone-replacement material. The scaffolds’ antimicrobial properties were evaluated against S. aureus and E. faecalis. The scaffolds possessed a sustained drug release from the scaffolds amounted to about 94% of the antibiotic’s total weight over a 4-week observation period. Agar diffusion confirmed the antimicrobial properties of the scaffolds against specific bacteria.

Keywords

• Electrospinning
• Hydroxyapatite
• Biologically soluble scaffolds
• Fibers
• Drugs