International Journal of Nanomedicine (Jul 2023)
Recent Advances for Dynamic-Based Therapy of Atherosclerosis
Abstract
Guanghao Wu,1,* Guanye Yu,2,* Meiling Zheng,3,* Wenhui Peng,2 Lei Li4 1School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, People’s Republic of China; 2Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine, Shanghai, 200072, People’s Republic of China; 3Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, 101121, People’s Republic of China; 4National Clinical Research Center for Obstetric & Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Li, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuai Fu Yuan, Eastern District, Beijing, 100730, People’s Republic of China, Tel +8613426328126, Fax +86 10 69158100, Email [email protected] Guanghao Wu, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, People’s Republic of China, Email [email protected]: Atherosclerosis (AS) is a chronic inflammatory disease, which may lead to high morbidity and mortality. Currently, the clinical treatment strategy for AS is administering drugs and performing surgery. However, advanced therapy strategies are urgently required because of the deficient therapeutic effects of current managements. Increased number of energy conversion-based organic or inorganic materials has been used in cancer and other major disease treatments, bringing hope to patients with the development of nanomedicine and materials. These treatment strategies employ specific nanomaterials with specific own physiochemical properties (external stimuli: light or ultrasound) to promote foam cell apoptosis and cholesterol efflux. Based on the pathological characteristics of vulnerable plaques, energy conversion-based nano-therapy has attracted increasing attention in the field of anti-atherosclerosis. Therefore, this review focuses on recent advances in energy conversion-based treatments. In addition to summarizing the therapeutic effects of various techniques, the regulated pathological processes are highlighted. Finally, the challenges and prospects for further development of dynamic treatment for AS are discussed.Keywords: atherosclerosis, nanomaterial, physiochemical, reactive oxygen species, energy conversion, therapy
