Nature Communications (Mar 2019)
Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
- Jinghua Lu,
- François Van Laethem,
- Abhisek Bhattacharya,
- Marco Craveiro,
- Ingrid Saba,
- Jonathan Chu,
- Nicholas C. Love,
- Anastasia Tikhonova,
- Sergei Radaev,
- Xiaoping Sun,
- Annette Ko,
- Tomer Arnon,
- Eric Shifrut,
- Nir Friedman,
- Nan-Ping Weng,
- Alfred Singer,
- Peter D. Sun
Affiliations
- Jinghua Lu
- Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases
- François Van Laethem
- Experimental Immunology Branch, National Cancer Institute
- Abhisek Bhattacharya
- Experimental Immunology Branch, National Cancer Institute
- Marco Craveiro
- Experimental Immunology Branch, National Cancer Institute
- Ingrid Saba
- Experimental Immunology Branch, National Cancer Institute
- Jonathan Chu
- Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases
- Nicholas C. Love
- Experimental Immunology Branch, National Cancer Institute
- Anastasia Tikhonova
- Experimental Immunology Branch, National Cancer Institute
- Sergei Radaev
- Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases
- Xiaoping Sun
- Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institute of Health
- Annette Ko
- Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institute of Health
- Tomer Arnon
- Department of Immunology, Weizmann Institute of Science
- Eric Shifrut
- Department of Immunology, Weizmann Institute of Science
- Nir Friedman
- Department of Immunology, Weizmann Institute of Science
- Nan-Ping Weng
- Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institute of Health
- Alfred Singer
- Experimental Immunology Branch, National Cancer Institute
- Peter D. Sun
- Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases
- DOI
- https://doi.org/10.1038/s41467-019-08906-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 of the pre-selection antigen receptors are essential for the selection of MHC-restricted repertoire.
