Senescence and entrenchment in evolution of amino acid sites

A. V. Stolyarova; E. Nabieva; V. V. Ptushenko; A. V. Favorov; A. V. Popova; A. D. Neverov; G. A. Bazykin

doi:10.1038/s41467-020-18366-z

Nature Communications (Sep 2020)

Senescence and entrenchment in evolution of amino acid sites

A. V. Stolyarova,
E. Nabieva,
V. V. Ptushenko,
A. V. Favorov,
A. V. Popova,
A. D. Neverov,
G. A. Bazykin

Affiliations

A. V. Stolyarova: Center of Life Sciences, Skolkovo Institute of Science and Technology
E. Nabieva: Center of Life Sciences, Skolkovo Institute of Science and Technology
V. V. Ptushenko: Department of Photochemistry and Photobiology, N. M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences
A. V. Favorov: Division of Biostatistics and Bioinformatics, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
A. V. Popova: Department of Molecular Diagnostics, Central Research Institute for Epidemiology
A. D. Neverov: Department of Molecular Diagnostics, Central Research Institute for Epidemiology
G. A. Bazykin: Center of Life Sciences, Skolkovo Institute of Science and Technology

DOI: https://doi.org/10.1038/s41467-020-18366-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Amino acid propensities at sites change over evolutionary time, due to epistatically interacting sites or environmental changes. Here, the authors develop an approach to distinguish between these, and model the fitness dynamics of each, then annotate indicative sites in vertebrate and insect genomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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