Nature Communications (Sep 2022)
Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns
- Geng Chen,
- Xiankun Wang,
- Qiwen Liao,
- Yunjun Ge,
- Haizhan Jiao,
- Qiang Chen,
- Yezhou Liu,
- Wenping Lyu,
- Lizhe Zhu,
- Gydo C. P. van Zundert,
- Michael J. Robertson,
- Georgios Skiniotis,
- Yang Du,
- Hongli Hu,
- Richard D. Ye
Affiliations
- Geng Chen
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- Xiankun Wang
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- Qiwen Liao
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- Yunjun Ge
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- Haizhan Jiao
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- Qiang Chen
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- Yezhou Liu
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- Wenping Lyu
- Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong
- Lizhe Zhu
- Warshel Institute for Computational Biology, School of Medicine, The Chinese University of Hong Kong
- Gydo C. P. van Zundert
- Schrödinger
- Michael J. Robertson
- Department of Molecular and Cellular Physiology, Stanford University School of Medicine
- Georgios Skiniotis
- Department of Molecular and Cellular Physiology, Stanford University School of Medicine
- Yang Du
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- Hongli Hu
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- Richard D. Ye
- Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-022-32822-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Detection of invading bacteria is key to immunity. Here, the authors report cryo-electron microscopy structures of agonist-bound formyl peptide receptor 1 (FPR1), that reveal structural basis for recognition of bacteria-derived formyl peptides.
