Molecules (Nov 2021)

Discovery of New Ginsenol-Like Compounds with High Antiviral Activity

  • Aleksandrina S. Volobueva,
  • Olga I. Yarovaya,
  • Marina V. Kireeva,
  • Sophia S. Borisevich,
  • Kseniya S. Kovaleva,
  • Iliya Ya. Mainagashev,
  • Yuri V. Gatilov,
  • Margarita G. Ilyina,
  • Vladimir V. Zarubaev,
  • Nariman F. Salakhutdinov

DOI
https://doi.org/10.3390/molecules26226794
Journal volume & issue
Vol. 26, no. 22
p. 6794

Abstract

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A number of framework amides with a ginsenol backbone have been synthesized using the Ritter reaction. We named the acetamide as Ginsamide. A method was developed for the synthesis of the corresponding amine and thioacetamide. The new compounds revealed a high activity against H1N1 influenza, which was confirmed using an animal model. Biological experiments were performed to determine the mechanism of action of the new agents, a ginsamide-resistant strain of influenza virus was obtained, and the pathogenicity of the resistant strain and the control strain was studied. It was shown that the emergence of resistance to Ginsamide was accompanied by a reduction in the pathogenicity of the influenza virus.

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