Sin Nombre Virus as Unlikely Reverse Zoonotic Threat

Abstract

We inoculated clinical materials into deer mice to attempt isolation of Sin Nombre virus. We did not observe productive infection in the natural rodent reservoir. Genomic comparisons between rodent reservoirs and human disease may provide insight into hantavirus evolution and genetic determinants, but reverse zoonosis of Sin Nombre virus appears unlikely.

Keywords

• Hantavirus
• Sin Nombre virus
• zoonotic disease
• rodentborne pathogens
• zoonoses
• viruses