PLoS ONE (Jan 2013)

Suicidal risk factors of recurrent major depression in Han Chinese women.

  • Yuzhang Zhu,
  • Hongni Zhang,
  • Shenxun Shi,
  • Jingfang Gao,
  • Youhui Li,
  • Ming Tao,
  • Kerang Zhang,
  • Xumei Wang,
  • Chengge Gao,
  • Lijun Yang,
  • Kan Li,
  • Jianguo Shi,
  • Gang Wang,
  • Lanfen Liu,
  • Jinbei Zhang,
  • Bo Du,
  • Guoqing Jiang,
  • Jianhua Shen,
  • Zhen Zhang,
  • Wei Liang,
  • Jing Sun,
  • Jian Hu,
  • Tiebang Liu,
  • Xueyi Wang,
  • Guodong Miao,
  • Huaqing Meng,
  • Yi Li,
  • Chunmei Hu,
  • Yi Li,
  • Guoping Huang,
  • Gongying Li,
  • Baowei Ha,
  • Hong Deng,
  • Qiyi Mei,
  • Hui Zhong,
  • Shugui Gao,
  • Hong Sang,
  • Yutang Zhang,
  • Xiang Fang,
  • Fengyu Yu,
  • Donglin Yang,
  • Tieqiao Liu,
  • Yunchun Chen,
  • Xiaohong Hong,
  • Wenyuan Wu,
  • Guibing Chen,
  • Min Cai,
  • Yan Song,
  • Jiyang Pan,
  • Jicheng Dong,
  • Runde Pan,
  • Wei Zhang,
  • Zhenming Shen,
  • Zhengrong Liu,
  • Danhua Gu,
  • Xiaoping Wang,
  • Xiaojuan Liu,
  • Qiwen Zhang,
  • Yihan Li,
  • Yiping Chen,
  • Kenneth Seedman Kendler,
  • Jonathan Flint,
  • Ying Liu

DOI
https://doi.org/10.1371/journal.pone.0080030
Journal volume & issue
Vol. 8, no. 11
p. e80030

Abstract

Read online

The relationship between suicidality and major depression is complex. Socio- demography, clinical features, comorbidity, clinical symptoms, and stressful life events are important factors influencing suicide in major depression, but these are not well defined. Thus, the aim of the present study was to assess the associations between the above-mentioned factors and suicide ideation, suicide plan, and suicide attempt in 6008 Han Chinese women with recurrent major depression (MD). Patients with any suicidality had significantly more MD symptoms, a significantly greater number of stressful life events, a positive family history of MD, a greater number of episodes, a significant experience of melancholia, and earlier age of onset. Comorbidity with dysthymia, generalized anxiety disorder (GAD), social phobia, and animal phobia was seen in suicidal patients. The present findings indicate that specific factors act to increase the likelihood of suicide in MD. Our results may help improve the clinical assessment of suicide risk in depressed patients, especially for women.