Agonist-antagonist myoneural interface surgery on the proprioceptive reconstruction of rat hind limb
Ping Wang,
Jianping Huang,
Jingjing Wei,
Qianhengyuan Yu,
Guanglin Li,
Bin Yu,
Lin Yang,
Zhiyuan Liu
Affiliations
Ping Wang
Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, China; Biomedical Sensing Engineering and Technology Research Center, Shandong University, Jinan, 25000, China
Jianping Huang
Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing, 100864, China
Jingjing Wei
Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing, 100864, China
Qianhengyuan Yu
Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing, 100864, China
Guanglin Li
Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing, 100864, China
Bin Yu
Biomedical Sensing Engineering and Technology Research Center, Shandong University, Jinan, 25000, China
Lin Yang
Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing, 100864, China; Corresponding author. the CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), No.1068 Xueyuan Avenue, Nanshan District, Shenzhen, 518000, China.
Zhiyuan Liu
Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing, 100864, China; Corresponding author. the CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), No.1068 Xueyuan Avenue, Nanshan District, Shenzhen, 518000, China.
Currently, prosthesis users rely on visual cues to control their prosthesis. One reason for this is that prostheses cannot provide users with proprioceptive functional signals. For this reason, we propose an agonist-antagonist myoneural interface (AMI) surgery. We examined how this surgery affects the restoration of motor function and proprioceptive reconstruction in the hind limb of Sprague–Dawley rats. The procedure entails grafting the soleus muscle, suturing the two tendon ends of the soleus muscle, and anastomosing the tibial and common peroneal nerves to the soleus muscle. We found that, following surgery, AMI rats exhibited improved neurological repair, shorter walking swings, braking, propulsion, and stance times, and greater compound action potentials than control rats. This means that in rats with neurological impairment of the hind limb, the proposed AMI surgical method significantly improves postoperative walking stability and muscle synergy. AMI surgery may become an option for regaining proprioception in the lost limb.
