Nature Communications (Nov 2021)
Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice
Abstract
The authors show that Trpm5, but not Trpm4, is the main Na+ -permeant channel mediating the warmth-activated ICaN in lumbar motoneurons. Trpm5 is also critical in generating plateau potentials in bistable motoneurons that are essential for producing a postural tone in hindlimbs and amplifying the locomotor output.