Nature Communications (Nov 2021)

Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice

  • Rémi Bos,
  • Benoît Drouillas,
  • Mouloud Bouhadfane,
  • Emilie Pecchi,
  • Virginie Trouplin,
  • Sergiy M. Korogod,
  • Frédéric Brocard

DOI
https://doi.org/10.1038/s41467-021-27113-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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The authors show that Trpm5, but not Trpm4, is the main Na+ -permeant channel mediating the warmth-activated ICaN in lumbar motoneurons. Trpm5 is also critical in generating plateau potentials in bistable motoneurons that are essential for producing a postural tone in hindlimbs and amplifying the locomotor output.