Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation

Frank Michael Lehmann; Nicole von Burg; Robert Ivanek; Claudia Teufel; Edit Horvath; Annick Peter; Gleb Turchinovich; Daniel Staehli; Tobias Eichlisberger; Mercedes Gomez de Agüero; Mairene Coto-Llerena; Michaela Prchal-Murphy; Veronika Sexl; Mohamed Bentires-Alj; Christoph Mueller; Daniela Finke

doi:10.1038/s41467-020-15612-2

Nature Communications (Apr 2020)

Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation

Frank Michael Lehmann,
Nicole von Burg,
Robert Ivanek,
Claudia Teufel,
Edit Horvath,
Annick Peter,
Gleb Turchinovich,
Daniel Staehli,
Tobias Eichlisberger,
Mercedes Gomez de Agüero,
Mairene Coto-Llerena,
Michaela Prchal-Murphy,
Veronika Sexl,
Mohamed Bentires-Alj,
Christoph Mueller,
Daniela Finke

Affiliations

Frank Michael Lehmann: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Nicole von Burg: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Robert Ivanek: Department of Biomedicine, University of Basel
Claudia Teufel: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Edit Horvath: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Annick Peter: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Gleb Turchinovich: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Daniel Staehli: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel
Tobias Eichlisberger: Friedrich Miescher Institute for Biomedical Research
Mercedes Gomez de Agüero: Maurice Müller Laboratories, Department for BioMedical Research, Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern
Mairene Coto-Llerena: Department of Biomedicine, University of Basel
Michaela Prchal-Murphy: Institute of Pharmacology and Toxicology, Department for Biomedical Sciences, University of Veterinary Medicine Vienna
Veronika Sexl: Institute of Pharmacology and Toxicology, Department for Biomedical Sciences, University of Veterinary Medicine Vienna
Mohamed Bentires-Alj: Department of Biomedicine, University of Basel
Christoph Mueller: Institute of Pathology, University of Bern
Daniela Finke: Department of Biomedicine and University Children’s Hospital of Basel, University of Basel

DOI: https://doi.org/10.1038/s41467-020-15612-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Group 3 innate lymphoid cells (ILC3s) promote T cell activation in the spleen but suppress it in the gut. Here, the authors show that this distinct regulation is mediated by gut microbiota-induced IL-23 and IFN-γ, respectively, and, along with the article by Rao et al, this work elucidates how cytokines set context specificity of ILC-T cell crosstalk by regulating ILC antigen presentation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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