مجلة التربية والعلم (Oct 2007)
Effects of Cadmium and Selenium on The Hematological Parameters and Histopathology of Liver in Male Rats
Abstract
Cadmium and Selenium are ubiquitous metals in the environmentI that induces a broad range of physiological dysfunctions. The purpose ofthis study was to investigate the chronic effect of Cadmium (Cd) andSelenium (Se) on rats blood parameters and histopathology of the liver in the male rats. Animals were divided at random into a control and treatedgroups (Cd and Se + Cd), both groups were fed with the same standardfood, but Cadmium chloride, and mixture of Cadmium chloride+Selenium chloride were added to the drinking water of the experimentalgroups. At the end of the experiments periods ( 28 days ) the animalswere sacrificed , blood samples were drawn via the dorsal vena cava ,Hematocrit ( Hct % ) , hemoglobin ( Hb ) , number of erythrocytes countand of erythrocytes count were determined . Liver was dissected out forhistological examination. There were different alteration in the bloodparameters among different treated animals (Cd and Se + Cd) and controlgroups .They differences were statistically significant (P:S 0.05) with Cdtreatment. Also results showed that the positive or negative alteration ofblood parameters was not significant for Se + Cd mixture treated ratsgroup.A number of morphological change were observed in the liver ,including a nuclear damage , necrosis and cell death at cadmiumtreatment and pronounced recovery after co-selenium supplementationindicted a considerable antagonistic effects .It can be concluded that the Cd exposure impair certainhemorheological mechanism and increase tissue damage in liver,although Selenium showed beneficial effects to some extend. Insummary, this study provides data on toxic effect in rats after dietary sublethal supplementation to heavy metals.
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