Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Maria Antonieta Ramírez-Morales; Anastasia E. Goldt; Polina M. Kalachikova; Javier A. Ramirez B.; Masashi Suzuki; Alexey N. Zhigach; Asma Ben Salah; Liliya I. Shurygina; Sergey D. Shandakov; Timofei Zatsepin; Dmitry V. Krasnikov; Toru Maekawa; Evgeny N. Nikolaev; Albert G. Nasibulin

doi:10.3390/nano12162869

Nanomaterials (Aug 2022)

Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Maria Antonieta Ramírez-Morales,
Anastasia E. Goldt,
Polina M. Kalachikova,
Javier A. Ramirez B.,
Masashi Suzuki,
Alexey N. Zhigach,
Asma Ben Salah,
Liliya I. Shurygina,
Sergey D. Shandakov,
Timofei Zatsepin,
Dmitry V. Krasnikov,
Toru Maekawa,
Evgeny N. Nikolaev,
Albert G. Nasibulin

Affiliations

Maria Antonieta Ramírez-Morales: Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Anastasia E. Goldt: Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Polina M. Kalachikova: Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Javier A. Ramirez B.: Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Masashi Suzuki: Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe 350-8585, Saitama, Japan
Alexey N. Zhigach: V.L. Talrose Institute for Energy Problems of Chemical Physics at Federal Research Center of Chemical Physics, Russian Academy of Sciences, Leninsky Prospect 38 Building 2, 119334 Moscow, Russia
Asma Ben Salah: Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe 350-8585, Saitama, Japan
Liliya I. Shurygina: Kemerovo State University, Krasnaya 6, 650043 Kemerovo, Russia
Sergey D. Shandakov: Kemerovo State University, Krasnaya 6, 650043 Kemerovo, Russia
Timofei Zatsepin: Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Dmitry V. Krasnikov: Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Toru Maekawa: Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe 350-8585, Saitama, Japan
Evgeny N. Nikolaev: Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Albert G. Nasibulin: Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia

DOI: https://doi.org/10.3390/nano12162869
Journal volume & issue: Vol. 12, no. 16
p. 2869

Abstract

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Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

Published in Nanomaterials

ISSN: 2079-4991 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: https://www.mdpi.com/journal/nanomaterials

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