Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy
Maria Antonieta Ramírez-Morales,
Anastasia E. Goldt,
Polina M. Kalachikova,
Javier A. Ramirez B.,
Masashi Suzuki,
Alexey N. Zhigach,
Asma Ben Salah,
Liliya I. Shurygina,
Sergey D. Shandakov,
Timofei Zatsepin,
Dmitry V. Krasnikov,
Toru Maekawa,
Evgeny N. Nikolaev,
Albert G. Nasibulin
Affiliations
Maria Antonieta Ramírez-Morales
Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Anastasia E. Goldt
Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Polina M. Kalachikova
Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Javier A. Ramirez B.
Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Masashi Suzuki
Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe 350-8585, Saitama, Japan
Alexey N. Zhigach
V.L. Talrose Institute for Energy Problems of Chemical Physics at Federal Research Center of Chemical Physics, Russian Academy of Sciences, Leninsky Prospect 38 Building 2, 119334 Moscow, Russia
Asma Ben Salah
Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe 350-8585, Saitama, Japan
Liliya I. Shurygina
Kemerovo State University, Krasnaya 6, 650043 Kemerovo, Russia
Sergey D. Shandakov
Kemerovo State University, Krasnaya 6, 650043 Kemerovo, Russia
Timofei Zatsepin
Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Dmitry V. Krasnikov
Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Toru Maekawa
Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe 350-8585, Saitama, Japan
Evgeny N. Nikolaev
Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Albert G. Nasibulin
Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia
Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.
