Nature Communications (May 2019)
6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda
- Shunmin He,
- Guoqiang Zhang,
- Jiajia Wang,
- Yajie Gao,
- Ruidi Sun,
- Zhijie Cao,
- Zhenping Chen,
- Xiudeng Zheng,
- Jiao Yuan,
- Yuewan Luo,
- Xiaona Wang,
- Wenxin Zhang,
- Peng Zhang,
- Yi Zhao,
- Chuan He,
- Yi Tao,
- Qinmiao Sun,
- Dahua Chen
Affiliations
- Shunmin He
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Guoqiang Zhang
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Jiajia Wang
- Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences
- Yajie Gao
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Ruidi Sun
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Zhijie Cao
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Zhenping Chen
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Xiudeng Zheng
- Centre for Computational and Evolutionary Biology, Key Laboratory of Animal Ecology and Conservational Biology, Institute of Zoology, Chinese Academy of Sciences
- Jiao Yuan
- Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences
- Yuewan Luo
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Xiaona Wang
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Wenxin Zhang
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Peng Zhang
- Key Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences
- Yi Zhao
- Advanced Computer Research Center, Institute of Computing Technology, Chinese Academy of Sciences
- Chuan He
- Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
- Yi Tao
- Centre for Computational and Evolutionary Biology, Key Laboratory of Animal Ecology and Conservational Biology, Institute of Zoology, Chinese Academy of Sciences
- Qinmiao Sun
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- Dahua Chen
- State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-019-10202-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
N6-methyladenine (6mA) DNA modification is a dynamic epigenetic mark in Drosophila embryos, but how 6mA is decoded is unclear. Here, the authors show that the protein Jumu binds 6mA-marked DNA to regulate the maternal-to-zygotic transition, partly through regulation the expression of the 6mA marked pioneer factor zelda.
