Serum iron fluctuations link ferroptosis process with mortality and prognosis of acute pancreatitis
Yueling Deng,
Tao Jiang,
Jinhao Li,
Pingping Yu,
Ying Mei,
Maojun Li,
Xiaoya Qi,
Fuyao Liu
Affiliations
Yueling Deng
Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Tao Jiang
Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Jinhao Li
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Pingping Yu
Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Ying Mei
Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Maojun Li
Linshui County People Hospital, Guangan, Sichuan, China
Xiaoya Qi
Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Corresponding author
Fuyao Liu
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Corresponding author
Summary: Recently, the existence of ferroptosis has been confirmed in chronic pancreatitis. However, its role in acute pancreatitis (AP) process, especially in critical status, has not yet been mentioned. To verify this hypothesis, we included 873 AP patients (training set) and 1,188 NAFLD patients (internal validation set) selected from MIMIC-III (Medical Information Mark for Intensive Care) database and 218 AP patients (external validation set) in Linshui County People’s Hospital ICU data. We analyzed the correlation between mortality and ferroptosis associating factors (such as serum iron, ALP, lactate, etc.) in them through regression analysis. In addition, to test the significance of these factors, the nomogram, AUC, and DCA analysis were applied. The results showed that serum iron, IBC, ALP, and lactate (p < 0.05) were independent factors for the mortality and prognosis of these patients. These correlations suggest ferroptosis and follow-up cell programmed death may own an important clinical interference significance among this population.
