Factors associated with chemotherapy toxicity in outpatients: a cohort study

Abstract

Objectives: to identify the occurrence of toxicity associated with chemotherapy and predictors factors of hospitalization, delayed treatment, abandonment, treatment suspension or death. Methods: 126 patients with cancer were in a prospective cohort study, conducted between July/2012 and january/2013, they were interviewed before treatment and after completion of the 1st, 2nd and 3rd cycles, when clinical, demographic and laboratory data were collected. Results: 39,7% had toxicity grade = 3. The latter led to more hospitalization, suspension, delayed treatment and death ( p <0,05). Performance status 2 in cycles 1 ( p <0,001) and 2 ( p =0,025) were risk factors to the toxicity grade = 3. When studied variables prior to first chemotherapy cycle, the body surface area < 1,69 m2 was associated with the occurrence of toxicity grade = 3 ( p =0,023) and with anemia ( p =0,044) and thrombocytopenia ( p =0,006) of any grade. Creatinine clearance < 50mL/min was associated with anemia ( p =0,032), BMI < 18,5kg/m2 with thrombocytopenia ( p =0,012), lymphocytes < 1500/mm3 to leukopenia ( p =0,017), neutrophils < 3100/mm3 to neutropenia ( p =0,002) and leukopenia ( p <0,001), all of any toxicity grade. Conclusion: Approximately 40% of patients had toxicity grade = 3, motivating more hospitalization, suspension, delayed treatment and death. Performance status 2 and body surface area < 1,69 m2 were related toxicity grade = 3.

Keywords

• Drug-Related Side Effects and Adverse Reactions
• Ambulatory Care
• Antineoplastic Agents
• Efeitos colaterais e reações adversas relacionados a medicamentos
• Assistência ambulatorial
• Agentes Antineoplásicos