Frontiers in Neuroscience (Mar 2022)

Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways

  • Dandan Zhang,
  • Dandan Zhang,
  • Yao Ji,
  • Xiongjin Chen,
  • RunSen Chen,
  • Yaxue Wei,
  • Qian Peng,
  • Juda Lin,
  • Jingwen Yin,
  • Hezhan Li,
  • Lili Cui,
  • Zhixiong Lin,
  • Yujie Cai

DOI
https://doi.org/10.3389/fnins.2022.844422
Journal volume & issue
Vol. 16

Abstract

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Circular RNAs (circRNAs) are highly expressed in the central nervous system and have been reported to be associated with neuropsychiatric diseases, but their potential role in major depressive disorder (MDD) remains unclear. Here, we demonstrated that there was a disorder of circRNAs in the blood of MDD patients. It has been preliminarily proved that hsa_circ_0002473, hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 were highly expressed in MDD patients and can be used as diagnostic markers for MDD. Bioinformatics analysis revealed that hsa_circ_0079651, hsa_circ_0137187, hsa_circ_0006010, and hsa_circ_0113010 may affect the neuroplasticity of MDD through the ceRNA mechanism.

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