Preservation of lymphocyte functional fitness in perinatally-infected and treated HIV+ pediatric patients displaying sub-optimal viral control

Aaruni Khanolkar; William J. Muller; Bridget M. Simpson; Jillian Cerullo; Ruth Williams; Sun Bae Sowers; Kiana Matthews; Sara Mercader; Carole J. Hickman; Richard T. D’Aquila; Guorong Liu

doi:10.1038/s43856-022-00085-9

Communications Medicine (Mar 2022)

Preservation of lymphocyte functional fitness in perinatally-infected and treated HIV+ pediatric patients displaying sub-optimal viral control

Aaruni Khanolkar,
William J. Muller,
Bridget M. Simpson,
Jillian Cerullo,
Ruth Williams,
Sun Bae Sowers,
Kiana Matthews,
Sara Mercader,
Carole J. Hickman,
Richard T. D’Aquila,
Guorong Liu

Affiliations

Aaruni Khanolkar: Department of Pathology, Ann and Robert H. Lurie Children’s Hospital of Chicago
William J. Muller: Division of Infectious Diseases, Ann and Robert H. Lurie Children’s Hospital of Chicago
Bridget M. Simpson: Department of Pathology, Ann and Robert H. Lurie Children’s Hospital of Chicago
Jillian Cerullo: Department of Pathology, Ann and Robert H. Lurie Children’s Hospital of Chicago
Ruth Williams: Division of Infectious Diseases, Ann and Robert H. Lurie Children’s Hospital of Chicago
Sun Bae Sowers: Viral Vaccine Preventable Diseases Branch, Division of Viral Diseases, National Center for Immunization & Respiratory Diseases, Centers for Disease Control and Prevention
Kiana Matthews: Viral Vaccine Preventable Diseases Branch, Division of Viral Diseases, National Center for Immunization & Respiratory Diseases, Centers for Disease Control and Prevention
Sara Mercader: Viral Vaccine Preventable Diseases Branch, Division of Viral Diseases, National Center for Immunization & Respiratory Diseases, Centers for Disease Control and Prevention
Carole J. Hickman: Viral Vaccine Preventable Diseases Branch, Division of Viral Diseases, National Center for Immunization & Respiratory Diseases, Centers for Disease Control and Prevention
Richard T. D’Aquila: Division of Infectious Diseases, Department of Internal Medicine, Feinberg School of Medicine, Northwestern University
Guorong Liu: Department of Pathology, Ann and Robert H. Lurie Children’s Hospital of Chicago

DOI: https://doi.org/10.1038/s43856-022-00085-9
Journal volume & issue: Vol. 2, no. 1
pp. 1 – 15

Abstract

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Khanolkar et al. compare the immune response in perinatally-infected HIV+ patients with differing patterns of virological control on treatment with antiretroviral therapy. Patients with sub-optimally suppressed HIV displayed no deficits in lymphocyte functional fitness.

Published in Communications Medicine

ISSN: 2730-664X (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://www.nature.com/commsmed/

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