Nature Communications (Nov 2021)
Network medicine for disease module identification and drug repurposing with the NeDRex platform
- Sepideh Sadegh,
- James Skelton,
- Elisa Anastasi,
- Judith Bernett,
- David B. Blumenthal,
- Gihanna Galindez,
- Marisol Salgado-Albarrán,
- Olga Lazareva,
- Keith Flanagan,
- Simon Cockell,
- Cristian Nogales,
- Ana I. Casas,
- Harald H. H. W. Schmidt,
- Jan Baumbach,
- Anil Wipat,
- Tim Kacprowski
Affiliations
- Sepideh Sadegh
- Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich
- James Skelton
- School of Computing, Newcastle University
- Elisa Anastasi
- School of Computing, Newcastle University
- Judith Bernett
- Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich
- David B. Blumenthal
- Department Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander University Erlangen-Nürnberg
- Gihanna Galindez
- Division Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics of Technische Universität Braunschweig and Hannover Medical School
- Marisol Salgado-Albarrán
- Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich
- Olga Lazareva
- Chair of Experimental Bioinformatics, TUM School of Life Sciences, Technical University of Munich
- Keith Flanagan
- School of Computing, Newcastle University
- Simon Cockell
- School of Biomedical, Nutrition and Sports Sciences, Faculty of Medical Sciences, Newcastle University
- Cristian Nogales
- Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University
- Ana I. Casas
- Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University
- Harald H. H. W. Schmidt
- Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience (MHeNs), Maastricht University
- Jan Baumbach
- Chair of Computational Systems Biology, University of Hamburg
- Anil Wipat
- School of Computing, Newcastle University
- Tim Kacprowski
- Division Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics of Technische Universität Braunschweig and Hannover Medical School
- DOI
- https://doi.org/10.1038/s41467-021-27138-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
There is an unmet need for adaptable tools allowing biomedical researchers to employ network-based drug repurposing approaches for their individual use cases. Here, the authors close this gap with NeDRex, an integrative and interactive platform.
