Nature Communications (Jun 2022)
Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters
- Weiwei Yu,
- Zhen Wang,
- Xiafei Yu,
- Yonghui Zhao,
- Zili Xie,
- Kailian Zhang,
- Zhexu Chi,
- Sheng Chen,
- Ting Xu,
- Danlu Jiang,
- Xingchen Guo,
- Mobai Li,
- Jian Zhang,
- Hui Fang,
- Dehang Yang,
- Yuxian Guo,
- Xuyan Yang,
- Xue Zhang,
- Yingliang Wu,
- Wei Yang,
- Di Wang
Affiliations
- Weiwei Yu
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Zhen Wang
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Xiafei Yu
- Department of Biophysics, and Department of Neurology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine
- Yonghui Zhao
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Zili Xie
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Kailian Zhang
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Zhexu Chi
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Sheng Chen
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Ting Xu
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Danlu Jiang
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Xingchen Guo
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Mobai Li
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Jian Zhang
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Hui Fang
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Dehang Yang
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Yuxian Guo
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Xuyan Yang
- Department of Rheumatology of the Second Affiliated Hospital, Zhejiang University School of Medicine
- Xue Zhang
- Department of Pathology and Pathophysiology, Zhejiang University School of Medicine
- Yingliang Wu
- State Key Laboratory of Virology, College of Life Sciences, Wuhan University
- Wei Yang
- Department of Biophysics, and Department of Neurology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine
- Di Wang
- Institute of Immunology and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-31149-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Potassium channels and membrane potential may influence macrophage function during inflammation. Here the authors show that the Kir2.1 potassium channel affects macrophage metabolism by altering cell surface retention of nutrient transporters and subsequently regulates inflammatory disease responses.
