Nature Communications (Nov 2017)
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
- Juan Liu,
- Cen Zhang,
- Yuhan Zhao,
- Xuetian Yue,
- Hao Wu,
- Shan Huang,
- James Chen,
- Kyle Tomsky,
- Haiyang Xie,
- Christen A. Khella,
- Michael L. Gatza,
- Dajing Xia,
- Jimin Gao,
- Eileen White,
- Bruce G. Haffty,
- Wenwei Hu,
- Zhaohui Feng
Affiliations
- Juan Liu
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Cen Zhang
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Yuhan Zhao
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Xuetian Yue
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Hao Wu
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Shan Huang
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- James Chen
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Kyle Tomsky
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Haiyang Xie
- Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine
- Christen A. Khella
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Michael L. Gatza
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Dajing Xia
- School of Public Health, Zhejiang University School of Medicine
- Jimin Gao
- Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Life Sciences, Wenzhou Medical University
- Eileen White
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Bruce G. Haffty
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Wenwei Hu
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- Zhaohui Feng
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey
- DOI
- https://doi.org/10.1038/s41467-017-01947-w
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
Parkin is an E3 ubiquitin ligase involved in Parkinson’s disease. Parkin has also been linked to cancer suppression but the mechanisms are unclear. Here the authors show that Parkin regulates HIF-1α through ubiquitin-dependent degradation, thus inhibiting metastasis of breast cancer cells.
