Functional disease architectures reveal unique biological role of transposable elements

Farhad Hormozdiari; Bryce van de Geijn; Joseph Nasser; Omer Weissbrod; Steven Gazal; Chelsea J. -T. Ju; Luke O’ Connor; Margaux L. A. Hujoel; Jesse Engreitz; Fereydoun Hormozdiari; Alkes L. Price

doi:10.1038/s41467-019-11957-5

Nature Communications (Sep 2019)

Functional disease architectures reveal unique biological role of transposable elements

Farhad Hormozdiari,
Bryce van de Geijn,
Joseph Nasser,
Omer Weissbrod,
Steven Gazal,
Chelsea J. -T. Ju,
Luke O’ Connor,
Margaux L. A. Hujoel,
Jesse Engreitz,
Fereydoun Hormozdiari,
Alkes L. Price

Affiliations

Farhad Hormozdiari: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Bryce van de Geijn: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Joseph Nasser: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
Omer Weissbrod: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Steven Gazal: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Chelsea J. -T. Ju: Department of Computer Science, University of California
Luke O’ Connor: Department of Epidemiology, Harvard T.H. Chan School of Public Health
Margaux L. A. Hujoel: Department of Biostatistics, Harvard T.H. Chan School of Public Health
Jesse Engreitz: Program in Medical and Population Genetics, Broad Institute of MIT and Harvard
Fereydoun Hormozdiari: Department of Biochemistry and Molecular Medicine, University of California
Alkes L. Price: Department of Epidemiology, Harvard T.H. Chan School of Public Health

DOI: https://doi.org/10.1038/s41467-019-11957-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 8

Abstract

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Transposable elements (TE) make up a large component of the human genome and have been shown to contribute to human diseases. Here, Hormozdiari et al. estimate the contribution of TEs to the heritability of 41 complex traits and diseases and find enrichment of SINEs in blood traits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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