Infection and Drug Resistance (May 2021)
Investigation and Analysis of the Colonization and Prevalence of Carbapenem-Resistant Enterobacteriaceae in Pediatric Liver Transplant Recipients
Abstract
Yan Sun,1,2 Lixin Yu,1,2 Wei Gao,1,2 Jinzhen Cai,1,2 Wentao Jiang,1,2 Wei Lu,3 Yihe Liu,1,2 Hong Zheng1,2 1Organ Transplantation Center, Tianjin First Central Hospital, Tianjin, 300192, People’s Republic of China; 2Tianjin Key Laboratory for Organ Transplantation, Tianjin, People’s Republic of China; 3Liver Cancer Treatment Centre, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of ChinaCorrespondence: Yihe Liu; Hong ZhengOrgan Transplantation Center, Tianjin First Central Hospital, No. 24 of Fukang Street, Nankai District, Tianjin, 300192, People’s Republic of ChinaTel/Fax +8602223627027Email [email protected]; [email protected]: This study aimed to investigate the colonization and prevalence of carbapenem-resistant Enterobacteriaceae (CRE) in pediatric liver transplant recipients and analyze the high-risk factors and prognosis of CRE infection.Methods: A prospective study involving 152 pediatric patients undergoing liver transplantation was carried out. Anal swab bacteria cultures were collected when the patients entered the intensive care unit (ICU) and when they left in order to screen for intestinal CRE colonization. The results were grouped according to the occurrence of CRE infection following surgery, and the patients were divided into two groups: a CRE infection group and a non-CRE infection group. Univariate analysis and multiple logistic regression analysis were conducted to determine the independent risk factors of CRE infection and analyze the survival rate.Results: Of the 152 pediatric liver transplant recipients enrolled in the study, there were 13 cases of postoperative CRE infection and 139 cases of non-CRE infection. The incidence of preoperative CRE infection, preoperative cytomegalovirus (CMV) infection, and preoperative sepsis in the CRE infection group was significantly higher than in the non-CRE infection group (P < 0.005). Intraoperative bleeding volume and operation times in the CRE infection group were also significantly higher than in the non-CRE infection group (P < 0.05). Furthermore, postoperative ICU treatment time, postoperative occurrence of unplanned surgery, postoperative mechanical ventilation of more than 24 hours, and the incidence of pre-ICU CRE colonization in the CRE infection group were significantly higher than in the non-CRE infection group (P < 0.05). Finally, the difference between the CRE infection group and the non-CRE infection group in six-month survival rate following surgery was significant (P < 0.001).Conclusion: The independent risk factors of CRE infection following pediatric liver transplantation include preoperative CRE infection and pre-ICU CRE colonization. CRE infection progresses quickly, with a poor prognosis and a high mortality rate. The CRE screening of anal swabs is crucial for the early detection of CRE infection.Keywords: carbapenem-resistant Enterobacteriaceae, CRE, liver transplantation, intestinal colonization, CT screening, anal swabs
