Clinical Medicine Insights: Reproductive Health (Jan 2013)

Live Birth from Previously Vitrified Oocytes, after Trophectoderm Biopsy, Revitrification, and Transfer of a Euploid Blastocyst

  • Jamie A. Grifo,
  • Brooke Hodes-Wertz,
  • Hsiao Ling Lee,
  • Esmeralda Ampeloquio,
  • Melicia Clarke-Williams,
  • Alexis Adler,
  • Santiago Munné,
  • Alan S. Berkeley

DOI
https://doi.org/10.4137/cmrh.s11919
Journal volume & issue
Vol. 7

Abstract

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Our objective is to describe a successful live birth from oocyte vitrification followed by thaw, fertilization, blastocyst culture, trophectoderm biopsy, vitrification, and subsequent thaw. Fifteen mature oocytes were frozen from a patient with uterine factor infertility. Thirteen oocytes survived the thaw, and five underwent trophectoderm biopsy and were refrozen. Three euploid embryos were obtained. A single euploid embryo was transferred in the second thaw cycle to a known recipient leading to the delivery of a normal male infant. This case report is proof of the concept that preimplantation screening and diagnosis is an option for fertility preservation patients.