Molecules
(Dec 2013)
Synthesis and Biological Activity of 3-[Phenyl(1,3-thiazol-2-yl)-amino]propanoic Acids and Their Derivatives
Vytautas Mickevičius,
Aušra Voskienė,
Ilona Jonuškienė,
Ramūnė Kolosej,
Jūratė Šiugždaitė,
Petras Rimantas Venskutonis,
Rita Kazernavičiūtė,
Zita Brazienė,
Elena Jakienė
Affiliations
Vytautas Mickevičius
Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania
Aušra Voskienė
Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania
Ilona Jonuškienė
Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania
Ramūnė Kolosej
Department of Organic Chemistry, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania
Jūratė Šiugždaitė
Lithuanian University of Health Sciences, Veterinary Academy, Tilžės 18, LT-47181 Kaunas, Lithuania
Petras Rimantas Venskutonis
Department of Food Technology, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania
Rita Kazernavičiūtė
Department of Food Technology, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania
Zita Brazienė
Lithuanian Research Centre for Agriculture and Forestry, Rumokai Experimental Station, Klausučiai, 70462 Vilkaviškis Distr., Lithuania
Elena Jakienė
Institute of Agricultural and Food Sciences, Aleksandras Stulginskis University, Studentų g. 11, LT-53361 Akademija, Kaunor., Lithuania
DOI
https://doi.org/10.3390/molecules181215000
Journal volume & issue
Vol. 18,
no. 12
Abstract
Read online
New N,N-disubstituted β-amino acids and their derivatives with thiazole, aromatic, and heterocyclic substituents were synthesized from N-phenyl-N-thiocarbamoyl-β-alanine by the Hantzsch method; derivatives with hydrazone fragments were also obtained. Some of the synthesized compounds exhibited discrete antimicrobial activity, and 3-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)(phenyl)amino]propanoic acid was found to promote rapeseed growth and to increase seed yield and oil content.
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