Features of the Pathogenetic Mechanisms of Regional Blood Flow Disturbances in Diabetic Foot Syndrome (Lliterature Review)

Abstract

Diabetes mellitus (DM) is recognized as one of the most important noninfectious disease in the world, the prevalence of which became pandemic. In the list of late complications of DM, diabetic foot syndrome is a leader, causing early disability and high mortality. According to the International Diabetes Federation, from 25 to 47 % of hospital admissions of patients with DM is associated with purulent-destructive lesions of the foot as a result of chronic tissue ischemia. This review highlights the main pathophysiological mechanisms of microcirculatory disorders in diabetic foot syndrome, which lead to critical lower limb ischemia.

Keywords

• diabetes mellitus
• diabetic foot syndrome
• microangiopathy
• macroangiopathy
• ischemia
• microcirculation