Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

Samuel K. Appiah; Charles Nkansah; Kofi Mensah; Felix Osei-Boakye; Dorcas Serwaa; Simon B. Bani; Gabriel Abbam; Samira Daud; Mandeiya D. A. Yakubu; Abraham B. Sagoe; Charles A. Derigubah; Yeduah Quansah; Vincent Kawuribi

doi:10.28991/SciMedJ-2022-04-02-02

SciMedicine Journal (Jun 2022)

Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

Samuel K. Appiah,
Charles Nkansah,
Kofi Mensah,
Felix Osei-Boakye,
Dorcas Serwaa,
Simon B. Bani,
Gabriel Abbam,
Samira Daud,
Mandeiya D. A. Yakubu,
Abraham B. Sagoe,
Charles A. Derigubah,
Yeduah Quansah,
Vincent Kawuribi

Affiliations

Samuel K. Appiah: 1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,
Charles Nkansah: 1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,
Kofi Mensah: 1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,
Felix Osei-Boakye: Department of Medical Laboratory Technology, Faculty of Applied Science and Technology, Sunyani Technical University, Sunyani,
Dorcas Serwaa: Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne,
Simon B. Bani: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale
Gabriel Abbam: Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale,
Samira Daud: Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale,
Mandeiya D. A. Yakubu: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale
Abraham B. Sagoe: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale
Charles A. Derigubah: Department of Medical Laboratory Technology, School of Applied Science and Arts, Bolgatanga Technical University, Bolgatanga,
Yeduah Quansah: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale
Vincent Kawuribi: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale

DOI: https://doi.org/10.28991/SciMedJ-2022-04-02-02
Journal volume & issue: Vol. 4, no. 2
pp. 63 – 72

Abstract

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Background: The ABO blood antigens may influence the levels of vWF: Ag and put individuals at risk of coagulopathies. This study assessed the plasma vWF: Ag and its relation with ABO blood antigens among healthy adults in northern Ghana. Methods: This cross-sectional study recruited 84 blood donors, aged 18–50 years, at Tamale Teaching Hospital. Blood groups were determined using the standard tube method, and a complete blood count was measured with an automated haematology analyzer. Sandwich ELISA was used to assess plasma vWF: Ag levels. The data obtained were analyzed using SPSS version 22. Results: The frequencies of O, A, B, and AB blood groups were 34 (40.5%), 25 (29.8%), 20 (23.8%), and 5 (6.0%), respectively. vWF: Ag levels were higher among the non-O than group O individuals (p = 0.008). Plasma vWF: Ag levels were lower in group O compared to AB (p = 0.015) and A (p = 0.013) individuals. Males had higher vWF: Ag levels than females (p = 0.002). A moderately positive correlation was observed between age and vWF levels (r = 0.497, pA>B>AB. Plasma vWF: Ag levels were higher in non-group O compared with group O individuals. Males had higher vWF: Ag levels, and a positive correlation between age and vWF: Ag was observed. Again, blood group O participants had lower neutrophil counts, but higher RDW-SD. The relationship between ABO blood phenotypes and plasma vWF: Ag should be considered in clinical practice. The establishment of separate reference intervals of vWF: Ag for the various phenotypes of ABO is recommended. Also, the study recommends further multicenter studies to assess the link between ABO phenotypes and all the endothelial cell parameters. Doi: 10.28991/SciMedJ-2022-04-02-02 Full Text: PDF

Published in SciMedicine Journal

ISSN: 2704-9833 (Online)
Publisher: Ital Publication
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Medicine: Public aspects of medicine
Website: https://scimedjournal.org

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